Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 3

Year

2019 1

2008 1

Keywords

FAK^6/7 1

SRRM4 1

breast 1

carcinogenesis 1

current status 1

differentiation block 1

hepato-pancreas 1

insulin 1

lineage 1

neuroendocrine neoplasms 1

organophosphate intoxication 1

pancreas 1

pancreas necrosis 1

percutaneous catheterization 1

sandostatin 1

severe acute pancreatitis 1

open ︾

Search scope:

排序： Display mode:

High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Frontiers of Medicine Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumors found in various organs, remains to be identified. Here, based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase (FAK) in The Cancer Genome Atlas datasets that contain 9193 patients of 33 cancer subtypes, we found that Box 6/Box 7-containing FAK variants (FAK^6/7) were observed in 7 (87.5%) of 8 pancreatic neuroendocrine carcinomas and 20 (11.76%) of 170 pancreatic ductal adenocarcinomas (PDACs). We tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumors, and found that FAK^6/7 was positive in 34 (75.6%) of 45 pancreatic NENs, 19 (47.5%) of 40 pancreatic solid pseudopapillary neoplasms, and 2 (2.9%) of 69 PDACs. We further tested FAK splicing variants in breast neuroendocrine carcinoma (BrNECs), and found that FAK^6/7 was positive in 14 (93.3%) of 15 BrNECs but 0 in 23 non-NEC breast cancers. We explored the underlying mechanisms and found that a splicing factor serine/arginine repetitive matrix protein 4 (SRRM4) was overexpressed in FAK^6/7-positive pancreatic tumors and breast tumors, which promoted the formation of FAK^6/7 in cells. These results suggested that FAK^6/7 could be a biomarker of NENs and represent a potential therapeutic target for these orphan diseases.

Keywords： FAK^6/7 SRRM4 neuroendocrine neoplasms pancreas breast

HTML PDF Collect

Stem cell research in hepatocellular carcinoma

SUN Chengyi, ZUO Shi

Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 1-4 doi: 10.1007/s11684-008-0001-6

Abstract: liver stem cell lineage: hepatocytes, hepatic stem cells/oval cells, bone marrow stem cells and hepato-pancreas

Keywords： lineage hepato-pancreas differentiation block carcinogenesis current status

HTML PDF Collect

Total pancreatic necrosis after organophosphate intoxication

Rui Hou, Hongmin Zhang, Huan Chen, Yuankai Zhou, Yun Long, Dawei Liu

Frontiers of Medicine 2019, Volume 13, Issue 2, Pages 285-288 doi: 10.1007/s11684-018-0626-z

Abstract: organophosphate intoxication are encountered occasionally in clinics, but very few of them develop into severe pancreasingestion of massive insecticides; she was considered to have total necrosis and function failure of the pancreas

Keywords： organophosphate intoxication severe acute pancreatitis pancreas necrosis percutaneous catheterization